ABSTRACT
FUNDAMENTOS: As glândulas sebáceas são suscetíveis à ação dos hormônios androgênios e apresentam proliferação benigna com a idade, ou seja, hiperplasia. OBJETIVOS: Estudo piloto para verificar se há correlação entre a taxa de hormônios masculinos circulantes e o aumento da incidência da hiperplasia das glândulas sebáceas. MÉTODOS: 16 pacientes do sexo feminino, com diagnóstico de hiperplasia sebácea cutânea, foram comparados a um grupo-controle de mesmo gênero e idades semelhantes, sem a doença. Ambos os grupos foram submetidos a testes de dosagem sanguínea para avaliação das taxas de hormônios androgênios circulantes (testosterona livre e total, androstenediona). Os resultados foram tabulados e analisados estatisticamente. RESULTADOS: Os dados demonstraram não haver mudanças nos níveis de hormônios masculinos circulantes dos pacientes com hiperplasia sebácea cutânea, quando comparados ao grupo-controle. CONCLUSÃO: Os dados sugerem que não há alterações estatisticamente significantes nas taxas dos hormônios circulantes (testosterona livre e total, androstenediona, deidroepiandrosterona, sulfato de deidroepiandrosterona) dos pacientes com hiperplasia sebácea cutânea.
BACKGROUND: The sebaceous glands are susceptible to the effects of androgens. A benign proliferation of these hormones, i.e. hyperplasia, occurs with age. OBJECTIVES: This was a pilot study to demonstrate whether any correlation exists between circulating androgen levels and an increase in the incidence of sebaceous hyperplasia. METHODS: Sixteen female patients with a diagnosis of sebaceous hyperplasia were compared to a control group of females of a similar age without the disease. Blood tests were performed on participants of both groups to measure circulating androgen levels (free and total testosterone and androstenedione levels). Results were tabulated for statistical analysis. RESULTS: These data showed no statistically significant differences in circulating androgen levels between the patients with sebaceous hyperplasia and the control group. CONCLUSION: These data suggest that no significant changes occur in circulating androgen levels [free and total testosterone, androstenedione, dehydroepiandrosterone (DHEA) and DHEA sulfate] in patients with sebaceous hyperplasia.
Subject(s)
Adult , Aged , Female , Humans , Middle Aged , Androstenedione/blood , Dihydrotestosterone/blood , Sebaceous Gland Diseases/pathology , Sebaceous Glands/pathology , Testosterone/blood , Biomarkers/blood , Case-Control Studies , Hyperplasia/blood , Hyperplasia/pathology , Pilot Projects , Prospective Studies , Sebaceous Gland Diseases/bloodABSTRACT
Se expone el caso clínico de un paciente de 67 años de edad el cual presenta múltiples lesiones papulares, redondeadas, de color amarillento, ubicadas en la mucosa de ambos carrillos (a la altura de los molares superiores y en cercanía con el conducto excretor Stenon de la glándula parótida) y en el fondo de ambos vestíbulos de la mandíbula. A estas lesiones se les dio el diagnóstico definitivo de: Gránulos de Fordyce. De igual manera, en este estudio y basándose en la bibliografía, se señalan en detalle las características clínicas e histológicas más relevantes de estas lesiones, a objeto de orientar al odontólogo en el diagnostico de las mismas para evitar que las confunda con verdaderas patologías
The clinical case of a 67 year old patient is presented. He suffers from multiple papule injuries, rounded, of yellowish color, located in the mucous of both cheeks (at the height of the superior molars and close to the Stenon excretory way of the parotid gland) and at heart of both lobbies of the jaw. These injuries were diagnosed as Fordyce Grains. Likewise, in this study and based on the literature, the clinical and histological details of these injuries are described in detail, in order to guide dentists in their diagnosis and so they do not confuse them with real pathologies.